Androstenediol (AED) prevents neuroendocrine-mediated suppression of the immune response to an influenza viral infection.
Identifieur interne : 002F01 ( Main/Exploration ); précédent : 002F00; suivant : 002F02Androstenediol (AED) prevents neuroendocrine-mediated suppression of the immune response to an influenza viral infection.
Auteurs : D A Padgett [États-Unis] ; J F SheridanSource :
- Journal of neuroimmunology [ 0165-5728 ] ; 1999.
Descripteurs français
- KwdFr :
- Agranulocytes (immunologie), Agranulocytes (métabolisme), Anabolisants (pharmacologie), Analyse de survie, Androstènediol (pharmacologie), Animaux, Axe hypophyso-surrénalien (immunologie), Axe hypophyso-surrénalien (virologie), Axe hypothalamohypophysaire (immunologie), Axe hypothalamohypophysaire (virologie), Cellules tueuses naturelles (immunologie), Cellules tueuses naturelles (virologie), Cinétique, Corticostérone (sang), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (mortalité), Interféron gamma (immunologie), Interféron gamma (métabolisme), Interleukine-10 (immunologie), Interleukine-10 (métabolisme), Maladies lymphatiques (immunologie), Maladies lymphatiques (virologie), Mâle, Souris, Souris de lignée C57BL, Stress physiologique (immunologie), Système neuroendocrinien (), Système neuroendocrinien (immunologie), Système neuroendocrinien (virologie), Tests de cytotoxicité immunologique, Tolérance immunitaire, Virus de la grippe A (immunologie).
- MESH :
- immunologie : Agranulocytes, Axe hypophyso-surrénalien, Axe hypothalamohypophysaire, Cellules tueuses naturelles, Infections à Orthomyxoviridae, Interféron gamma, Interleukine-10, Maladies lymphatiques, Stress physiologique, Système neuroendocrinien, Virus de la grippe A.
- mortalité : Infections à Orthomyxoviridae.
- métabolisme : Agranulocytes, Interféron gamma, Interleukine-10.
- pharmacologie : Anabolisants, Androstènediol.
- sang : Corticostérone.
- virologie : Axe hypophyso-surrénalien, Axe hypothalamohypophysaire, Cellules tueuses naturelles, Maladies lymphatiques, Système neuroendocrinien.
- Analyse de survie, Animaux, Cinétique, Mâle, Souris, Souris de lignée C57BL, Système neuroendocrinien, Tests de cytotoxicité immunologique, Tolérance immunitaire.
English descriptors
- KwdEn :
- Anabolic Agents (pharmacology), Androstenediol (pharmacology), Animals, Corticosterone (blood), Cytotoxicity Tests, Immunologic, Hypothalamo-Hypophyseal System (immunology), Hypothalamo-Hypophyseal System (virology), Immune Tolerance, Influenza A virus (immunology), Interferon-gamma (immunology), Interferon-gamma (metabolism), Interleukin-10 (immunology), Interleukin-10 (metabolism), Killer Cells, Natural (immunology), Killer Cells, Natural (virology), Kinetics, Leukocytes, Mononuclear (immunology), Leukocytes, Mononuclear (metabolism), Lymphatic Diseases (immunology), Lymphatic Diseases (virology), Male, Mice, Mice, Inbred C57BL, Neurosecretory Systems (drug effects), Neurosecretory Systems (immunology), Neurosecretory Systems (virology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (mortality), Pituitary-Adrenal System (immunology), Pituitary-Adrenal System (virology), Stress, Physiological (immunology), Survival Analysis.
- MESH :
- chemical , blood : Corticosterone.
- chemical , immunology : Interferon-gamma, Interleukin-10.
- chemical , metabolism : Interferon-gamma, Interleukin-10.
- chemical , pharmacology : Anabolic Agents, Androstenediol.
- drug effects : Neurosecretory Systems.
- immunology : Hypothalamo-Hypophyseal System, Influenza A virus, Killer Cells, Natural, Leukocytes, Mononuclear, Lymphatic Diseases, Neurosecretory Systems, Orthomyxoviridae Infections, Pituitary-Adrenal System, Stress, Physiological.
- metabolism : Leukocytes, Mononuclear.
- mortality : Orthomyxoviridae Infections.
- virology : Hypothalamo-Hypophyseal System, Killer Cells, Natural, Lymphatic Diseases, Neurosecretory Systems, Pituitary-Adrenal System.
- Animals, Cytotoxicity Tests, Immunologic, Immune Tolerance, Kinetics, Male, Mice, Mice, Inbred C57BL, Survival Analysis.
Abstract
The goal of these studies was to analyze the ability of androstenediol (AED) to counter-regulate the influences of stress on anti-viral immune responses. Male C57BL/6 mice, treated with 320 mg/kg AED were infected with influenza virus and subjected to repeated cycles of restraint (RST). AED blocked RST-mediated suppression of cell recruitment to the draining lymph node, lung NK cell activity, and CD4 + T cell activation. In addition, mice treated with AED had lower pre-corticosterone levels as compared to vehicle controls and the RST-mediated elevation of corticosterone was significantly blunted by AED treatment. These data suggest that AED functions to augment anti-viral immune responses by counter-regulating glucocorticoid function.
DOI: 10.1016/s0165-5728(99)00068-5
PubMed: 10430045
Affiliations:
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Le document en format XML
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Systems</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cytotoxicity Tests, Immunologic</term><term>Immune Tolerance</term><term>Kinetics</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de survie</term><term>Animaux</term><term>Cinétique</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Système neuroendocrinien</term><term>Tests de cytotoxicité immunologique</term><term>Tolérance immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The goal of these studies was to analyze the ability of androstenediol (AED) to counter-regulate the influences of stress on anti-viral immune responses. Male C57BL/6 mice, treated with 320 mg/kg AED were infected with influenza virus and subjected to repeated cycles of restraint (RST). AED blocked RST-mediated suppression of cell recruitment to the draining lymph node, lung NK cell activity, and CD4 + T cell activation. In addition, mice treated with AED had lower pre-corticosterone levels as compared to vehicle controls and the RST-mediated elevation of corticosterone was significantly blunted by AED treatment. These data suggest that AED functions to augment anti-viral immune responses by counter-regulating glucocorticoid function.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Sheridan, J F" sort="Sheridan, J F" uniqKey="Sheridan J" first="J F" last="Sheridan">J F Sheridan</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Padgett, D A" sort="Padgett, D A" uniqKey="Padgett D" first="D A" last="Padgett">D A Padgett</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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